![]() ![]() Sponges host an exceptionally rich and diverse associated microbiota, together referred to as a ‘holobionts’ 1, and are frequently grouped into high and low microbial abundance sponges (HMA and LMA sponges). Sponges (phylum Porifera) are sessile filter-feeding animals found worldwide in shallow and deep, marine and freshwater habitats. barretti suggested members of Acidobacteria, Proteobacteria, Chloroflexi, or an unclassified prokaryote as potential producers. Correlations between prokaryotic community and the bioactive compounds in G. Other metabolites varying with depth were compatible solutes regulating osmolarity of the cells. The metabolome varied with depth, with relative quantities of known bioactive compounds increasing or decreasing strongly. Up to 35.5% of microbial ASVs (amplicon sequence variants) showed significant changes with depth while phylum-level composition of host microbiome remained unchanged. Both prokaryotic communities and metabolome varied significantly with depth, which we hypothesized to be the effect of different water masses. Using 16S rRNA gene amplicon sequencing and untargeted metabolomics, we assessed prokaryotic and chemical diversities in three deep-sea sponge species: Geodia barretti, Stryphnus fortis, and Weberella bursa. Here, we investigated the changes of microbiota and metabolomes in sponges along a depth range of 1232 m. Yet, environmental influences on the sponge-associated microbiota and bioactive compound production remain elusive. Their often rich and species-specific microbiota is hypothesised to be producing many of these compounds. Marine sponges (phylum Porifera) are leading organisms for the discovery of bioactive compounds from nature. ![]()
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